Dr. Jothi Lakshmi Nallasivam

E-mail: jothi@nitt.edu

 

Research Interest

  • Transition Metal Catalysis
  • Cross Coupling
  • Designing Novel Methodology
  • Synthesis of Bioactive Natural Products

 

Education:

Ph.D:  Mentor: Prof. Rodney A. Fernandes, Indian Institute of Technology Bombay, Maharashtra, India.

M.Sc: Mentor: Prof. Y. B. Basavaraju, Manasagangothri, University of Mysore, Karnataka

 

Research Grant

1. DST-SERB-CRG: CRG/2021/008121 (2021-2024 ongoing, 3-Years, 39.4 Lakhs)

2. NITT-Intitute Seed Grant (2021-2023 ongoing, 2 Years, 5 Lakhs)

3. DST-SERB-NPDF (2017-2019, 2-Years, 19.8 Lakhs)

 

Research Experience:

  • Postdoctoral Fellow: ″Titanium Mediated Radical cyclization″ Mentor: Prof. Tushar Kanti Chakraborty, Indian Institute of Science (IISc), Bangalore
  • CSIR-JRF and SRF: ″Development of Asymmetric Allylation, Bis-allylation, aza-Cope/aza-Prins Cyclization, Suzuki-Miyaura Coupling, Mono and Bis-arylation of γ-Vinyl-γ-butyrolactone″ Mentor: Prof. Rodney A. Fernandes, Indian Institute of Technology Bombay
  • CSIR-JRF: Mentor: Prof. Rodney A. Fernandes, IRCC, Indian Institute of Technology Bombay
  • Scientist: Syngene International Limited, Bangalore

 

Teaching: 20 May 2020 to till date

Assistant Professor, Department of Chemistry, NIT Tiruchirappalli

 

B.Tech 1st-Year

CHIR11 Chemistry Theory (Semester 1 & 2)

CHIR12 Chemistry Laboratory (Semester 1 & 2)

  • CSE 2019-23, Section - A, Jan-2020, S2
  • ME 2020-24, Section - A, July-2020, S1
  • EEE 2020-24, Section - B, Jan-2021, S2
  • ME 2021-2025, Section - B, July-2021, S1
  • EEE 2021-25, Section - B, Jan-2022, S2

 

Theory: M.Sc & Ph.D

CH629 Polymer Chemistry (Semester 3)

  • M.Sc 2019-21 & 2020-22 July-2020 & 2021, S3
  • Ph.D 2020-24 & 2021-25 July-2020 & 2022

CH625 Medicinal Chemistry (Semester 3)

  • M.Sc 2021-2 & 2022-24 July Session, S3
  • Ph.D 2022-26 & 2023-27 July Session

 

Laboratory: M.Sc 1st & 2nd Year

CH609 Organic Preparation and Separation Laboratory

M.Sc 2020-22, Jan-2021, S1

CH612 Analytical Chemistry Laboratory

M.Sc 2022-2, Jan-2022, S2

 

Ph.D Ongoing

1. Kiruthika Nachimuthu, PhD-August 2022, PMRF Awardee July 2023  

2. Kavya Shanmugam,  DST-Project, PhD- July 2023

 

DST Project Fellow

1. Sanjutha Radhakrishnan, DST-Project JRF, August 2023

 

Post-graduate (M.Sc) Project-NITT

1. Mopi Lollen (M.Sc 2019-2021, S4)

2. Keerthivasan (M.Sc 2020-2022, S4)

3. Sivaranjani (M.Sc 2020-2022, S4)

4. Abhilasha Chalke (M.Sc 2021-2023, S4)

5. Vinod Kashyap (M.Sc 2021-2023, S4)

 

Project Internship Students

1. Kirubakar,  Integrated M. Sc, SVNIT May 2023

2. Amrutha, M.Sc, Amrutha vidyapeetam Coimbatore, May 2023

3. Sukanya Sasi, Integrated M. Sc, Amrutha vidyapeetam Coimbatore, May 2023

4. Aarya, B.Sc, St. Joseph College Trichy, May 2023

5. Agash, B.Sc, St. Joseph College Trichy, May 2023

 

Honors and Awards

2017: Awarded National Postdoctoral Fellowship (DST-SERB-NPDF)

2017: PhD Best Thesis Award, IIT Bombay

2012: Awarded as Senior Research Fellow (CSIR, July−2012 to July−2015), New Delhi.

2010: Awarded as Junior Research Fellow (CSIR, July−2010 to July−2012), New Delhi.

2009: Awarded as Junior Research Fellow (IRCC-IIT Bombay April 2009 to July 2010).

2009: Qualified National Eligibility Test (CSIR-LS-NET, July–2009), New Delhi.

2009: Qualified GATE 2009 examination.

 

Publications:

  1. (‒)-β-Pinene-based π-Allylpalladium Complex-Catalyzed Asymmetric Allylation of Bis-Imines. Nallasivam, J. L.; Fernandes R. A.* ChemistrySelect, 2020 doi.org/10.1002/slct.202002599).
  2. Titanocene(III)-Mediated 5-exo-trig Radical Cyclization: En Route to Spirooxindole-Based Tetrahydrofuran and Bicyclic Lactone. Nallasivam, J. L.; Chakraborty, T. K.* J. Org. Chem. 2019. (DOI:10.1021/acs.joc.9b02608).
  3. Catalytic Allylic Functionalization via π -Allyl Palladium Chemistry. Nallasivam, J. L.; Fernandes R. A.* Org. Biomol. Chem. 2019, 17, 8647. (DOI: 10.1039/c9ob01725a).
  4. Synthetic Modifications of Bifunctional Homoallylamines: Synthesis of 2-Arylpiperidines, (R)-Anatabine and (R)-Anabasine. Nallasivam, J. L.; Fernandes R. A.* Synth. Commun. 2019, 49, 2815. (DOI:10.1080/00397911.2019.1643890).
  5. A Protective-Group-Free Synthesis of Paraconic acids: Synthesis of (+)-Methylenolactocin, (+)-Phaseolinic acid, (+)-Nephrosteranic acid, (+)-Rocellaric acid, (+)-Nephrosterinic acid and (+)-Protolichesterinic acid. Nallasivam, J. L.; Fernandes R. A.* Org. Biomol. Chem. 2017, 15, 708. (DOI: 10.1039/c6ob02398c).
  6. Pd-Catalyzed Site-Selective Mono Allylic Substitution and Bis-Arylation by Allylic Directed C-H Activation of g-Vinyl-g-Lactone: Synthesis of g-(Aryl,Styryl)-β-Hydroxy Acids and Highly Substituted Tetrahydrofurans. Nallasivam, J. L.; Fernandes R. A.* J. Am. Chem. Soc. 2016, 138, 13238 (DOI: 10.1021/jacs.6b06438).
  7. A Concise Synthesis of Incrustoporin and its Analogues via Suzuki-Miyaura Coupling. Nallasivam, J. L.; Fernandes R. A.* ChemistrySelect, 2016, 1, 5137 (DOI: 10.1002/slct.201601379).
  8. Unimolecular 4-Hydroxy Piperidines:  New Ligands for Copper Catalyzed N-Arylation. Patil, P. H.; Nallasivam, J. L.; Fernandes, R. A.* Asian J. Org. Chem. 2015, 6, 552 (DOI: 10.1002/ajoc.201580601).
  9. Development of Unimolecular Tetrakis-Piperidine-4-ol as New Ligand for Suzuki-Miyaura Cross Coupling Reaction: Synthesis of Incrustoporin and Preclamol. Nallasivam, J. L.; Fernandes, R. A.* Eur. J. Org. Chem. 2015, 3558 (DOI: 10.1002/ejoc.201500353).
  10. A Cascade Aza-Cope/Aza-Prins Cyclization Leads to Piperidine Derivatives. Nallasivam, J. L.; Fernandes, R. A.* Eur. J. Org. Chem. 2015, 2012 (DOI: 10.1002/ejoc.201403607)
  11. Enantioselective Allylation of Imines Catalyzed by Newly Developed (−)-β-Pinene-Based π-Allylpalladium Catalyst: An Efficient Synthesis of (R)-α-Propylpiperonylamine and (R)-Pipecolic acid. Nallasivam, J. L.; Fernandes, R. A.* Org. Biomol. Chem. 2012, 10, 7789 (DOI: 10.1039/c2ob26188j).
  12. One-Pot Tandem Aldol-Cycloetherification Protocol in the Enantioselective Synthesis of Davanoids . Singh, V. K.;  Nallasivam, J. L.;  Chakraborty, T. K. J. Org. Chem. 2023, 88, 3068.

 

Conferences/Seminars/Symposia Parcipited:

Oral Presentation:

  • Nallasivam, J. L.; Fernandes, R. A. "Aymmetric Allylation of Imines Catalyzed by Chiral π-Allyl Palldium Complexes." ACS on Campus, January 20th, 2016, IIT Bombay, Mumbai, India.
  • Nallasivam, J. L.; Fernandes, R. A. "A Cascade Reactions and its Application in Suzuki-Miyaura Cross Coupling Reactions."  28th RSM 2016, February 12-13th, 2016, Takur College of Science and Commerce, Mumbai, India.
  • Nallasivam, J. L.; Fernandes, R. "A Cascade aza-Cope/aza-Prins Cyclization Leads to Piperidine Derivatives: New Ligands for Suzuki-MiyauraCross Coupling Reactions." RAICS 2015 August 21-23rd, 2015, MNIT, Jaipur, India.

 

Poster Presention:

  • Nallasivam, J. L.; Fernandes, R. A. "A Cascade aza-Cope/aza-Prins Cyclization Leads to Piperidine Derivatives: New Ligands for Suzuki-Miyaura Cross Coupling Reactions." 16th Tetrahedron Symposium; Asia Edition, November 10-13th, 2015, Shanghai Institute of Organic Chemistry, China.
  • Nallasivam, J. L.; Fernandes, R. A. "Asymmetric catalysis and its applications in natural product synthesis.″ 16th CRSI National Symposium in Chemistry (NSC-15), February 7-9th, 2014, IIT Bombay, India.
  • Nallasivam, J. L.; Fernandes, R. A. "Enantioselective Allylation of Imines Catalyzed by (-)-Pinene Based π-AllylPalladium Catalyst: An Efficient Synthesis of (R)-α-Propylpiperonylamine and (R)-Pipecolic Acid." 10th J-NOST Symposium in Chemistry, December 4-6th, 2014, IIT Madras, India.
  • Nallasivam, J. L.; Fernandes, R. A. "Enantioselective Allylation of Imines Catalyzed by (-)-Pinene Based π-Allyl Palladium Complexes." 15th CRSI National Symposium in Chemistry (NSC-15), February 1-3rd, 2013, Banaras Hindu University, Varanasi, Uttar Pradesh, India.
  • Nallasivam, J. L.; Fernandes, R. A.  "Development  of  Menthane  and  (-)-Pinene  Based  Chiral  π-Allyl  Palladium Catalysis in Asymmetric Allylation." Nallasivam, J. L.; Fernandes, R. A. IITB-ACS Symposium, October 2nd, 2012, IIT Bombay, Mumbai, India.
  • Nallasivam, J. L.; Fernandes, R. A. "(-)-β-Pinane Based Chiral π-Allyl Palladium Complexes Catalyzed Asymmetric Allylation of Imines." Nallasivam, J. L.; Fernandes, R. A. 3rd Indo-German Symposium on Frontiers of Chemistry, September 27-28th, 2011, IIT Bombay, India.

 

Contact:

Dr. Jothi Lakshmi Nallasivam

OJAS, Room. No. CH 215, Department of Chemistry

National Institute of Technology Tiruchirapalli

NIT campus 620015

Tamilnadu, India.

 

 

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